Beyond Weight Loss: The Longevity Question
GLP-1 medications like Ozempic, Wegovy, and Mounjaro are revolutionizing weight loss - but do they actually reverse biological aging?
Inflammation Reduction
Weight loss dramatically reduces chronic inflammation - a key driver of accelerated aging measured by GrimAge.
Metabolic Reset
GLP-1s improve insulin sensitivity, glucose control, and lipid profiles - all factors that influence epigenetic aging.
Cardiovascular Benefits
SELECT trial showed 20% CV event reduction - but is this just weight loss or something more? GrimAge can help answer this.
Why Track Biological Age on GLP-1s?
You're investing in your health with GLP-1 therapy. Now quantify the return on that investment with rigorous biological age tracking.
Answer the Big Question
Does weight loss from GLP-1s actually reverse biological aging, or just improve symptoms?
Track Progress Beyond the Scale
Weight fluctuates, but biological age shows the deeper metabolic transformation
Compare GLP-1s
Help determine if semaglutide, tirzepatide, or others have different aging effects
Contribute to Science
Help generate the first large-scale data on GLP-1s and epigenetic aging
Related Research
Track Your Transformation
Quarterly testing throughout your GLP-1 journey
Baseline
GrimAge test before or early in GLP-1 treatment
3 Months
First follow-up during rapid weight loss phase
6 Months
Mid-study assessment as metabolic changes stabilize
12 Months
Final assessment - quantify your biological age change
Quantify Your GLP-1 Journey
You're already on the cutting edge with GLP-1 therapy. Now be on the cutting edge of understanding what it does to your biological age.
Study Eligibility
- Currently on or starting semaglutide, tirzepatide, or other GLP-1
- BMI 27+ (or 25+ with metabolic condition)
- Willing to complete 4 blood draws over 12 months
- Planning to continue GLP-1 therapy for at least 6 months
Early enrollees receive discounted testing rates
Frequently Asked Questions
Will GLP-1s definitely reduce my biological age?
We don't know yet - that's why this study is important! Weight loss generally reduces biological age, and GLP-1s have effects beyond weight loss. This study will help determine if GLP-1s produce epigenetic age reversal.
Which GLP-1 medications are included?
All GLP-1 receptor agonists are welcome: semaglutide (Ozempic, Wegovy, Rybelsus), tirzepatide (Mounjaro, Zepbound), liraglutide (Victoza, Saxenda), and others. We'll analyze results by medication type.
Can I join if I've already been on GLP-1 for a while?
Yes, though ideally we prefer participants early in their GLP-1 journey to capture baseline and changes. If you've been on GLP-1s for over 6 months, we may place you in a maintenance tracking cohort instead.
Do I need to share my results publicly?
No. Your individual results are private. We use anonymized, aggregate data for research publications. You own your data and can choose whether to share it.
What if I stop taking my GLP-1 during the study?
That's actually valuable data! We want to understand how biological age changes both on and off GLP-1 therapy. Please continue with scheduled tests even if you discontinue medication.