What's Included
Everything you need to track your biological aging journey
3 PhenoAge Tests
Blood plasma biological age tests at baseline, midpoint, and endpoint to track your progress.
Wearables Tracking
Connect your fitness tracker to monitor sleep, activity, and stress throughout the study.
Monthly Reports
Receive detailed reports with biomarker data and personalized aging insights.
Longitudinal Analysis
Personalized reports showing your biological aging trajectory over the study period.
Group Analysis
Final comprehensive report showing group-level results and statistical analysis.
GrimAge Discount
Up to 25% off additional GrimAge tests for deeper epigenetic analysis.
6-Month Study Timeline
A structured program to evaluate the effects of Ca-AKG supplementation on your biological age.
Month 0: Baseline
Complete initial PhenoAge test and health survey. Connect wearables.
Months 1-2: Observation
Track baseline metrics. Receive first monthly reports.
Month 3: Midpoint Test
Second PhenoAge test. Compare early results.
Months 4-5: Continuation
Continue tracking with detailed monthly insights.
Month 6: Final Analysis
Final PhenoAge test and comprehensive results report.
Important Note
Participants will be responsible for purchasing their own supply of Ca-AKG (Alpha-Ketoglutarate) at an estimated cost of $30-$50 per month.
About Ca-AKG
Alpha-Ketoglutarate is a naturally occurring molecule involved in cellular energy production. Research has shown potential anti-aging effects, including a notable study suggesting biological age reversal. This group study aims to replicate and validate these findings in a real-world setting.
Testing Methodology
Understanding the biological age tests used in this study
PhenoAge
Clinical biomarker-based biological age test
- Uses 9 blood biomarkers
- Measures disease onset risk
- Fast results (~1 week)
- Cost-effective for tracking
GrimAge
Epigenetic DNA methylation analysis
- DNA methylation markers
- Mortality risk prediction
- Gold standard accuracy
- Deep aging insights
Clock Foundation
Clock Foundation is a nonprofit longevity research organization founded by Dr. Steve Horvath (creator of the Horvath Clock and GrimAge) and Bobby Brooke. Our mission is to accelerate longevity research through community-driven studies and accessible biological age testing.
Learn more about our researchDisease-Specific GrimAge Monitoring
These are cohorts within the HLTHSPN Healthspan Study. GrimAge is especially responsive to major health interventions—join the cohort most relevant to your situation.
Smoking Cessation
Track biological age recovery after quitting smoking—the largest known effect on GrimAge.
Bariatric Surgery
Document biological age reversal following surgical weight loss intervention.
Sleep Apnea (CPAP)
Track CPAP treatment effects on biological age and sleep-related aging markers.
Menopause & HRT
Monitor hormonal transition effects and HRT impact on biological aging.
GLP-1 & Obesity
Track biological age changes with semaglutide and tirzepatide treatment.
HIV & ART
Monitor biological age for people living with HIV on antiretroviral therapy.
PTSD & Veterans
Track biological age in veterans and trauma survivors undergoing treatment.
Depression
Monitor biological age during major depression treatment and remission.
COPD
Track biological age in chronic lung disease with treatment optimization.
Ready to Join?
Be part of groundbreaking longevity research. Sign up for the Ca-AKG Open Enrollment Group today.
This is a community research study, not a clinical trial. Results are for research purposes only. Consult with a healthcare provider before starting any supplement regimen.