Bryan Johnson Blueprint Stack

This longevity protocol appears to target multiple aspects of aging, including metabolic health, cellular function, and inflammation. The inclusion of supplements like CoQ10, Creatine, and N-acetylcysteine suggests an aim to support energy production and antioxidant defenses. Other components, such as Glucosamine and Calcium Alpha-Ketoglutarate, are often associated with joint health and muscle maintenance, while Ashwagandha and Melatonin are commonly used for stress management and sleep regulation. The presence of Lycopene, Curcumin, and Aged Garlic Extract indicates a focus on reducing oxidative stress and inflammation.

The strength of evidence supporting the individual components of this protocol varies significantly. Metformin stands out with a substantial body of research, suggesting a relatively strong evidence base for its potential role in longevity. NMN also has a growing, though smaller, body of evidence. In contrast, Acarbose, Aged Garlic Extract, Ashwagandha, Calcium Alpha-Ketoglutarate, CoQ10, Creatine Monohydrate, Curcumin, Fisetin, Glucosamine Sulfate, Lithium Orotate, Lycopene, and Melatonin have very limited or no direct research findings specifically related to longevity, indicating a need for further investigation to determine their efficacy in this context. N-acetylcysteine has a small amount of research.